John C Lieske Selected Research

Kidney Calculi (Kidney Stone)

9/2022	Estimated GFR Slope Across CKD Stages in Primary Hyperoxaluria Type 1.
3/2022	Randomized Clinical Trial on the Long-Term Efficacy and Safety of Lumasiran in Patients With Primary Hyperoxaluria Type 1.
1/2022	The genetics of kidney stone disease and nephrocalcinosis.
2/2021	Correction to: Specific populations of urinary extracellular vesicles and proteins differentiate type 1 primary hyperoxaluria patients without and with nephrocalcinosis or kidney stones.
1/2021	Lumasiran, an RNAi Therapeutic for Primary Hyperoxaluria Type 1.
1/2021	In Vivo Entombment of Bacteria and Fungi during Calcium Oxalate, Brushite, and Struvite Urolithiasis.
1/2021	Human kidney stones: a natural record of universal biomineralization.
1/2021	Phase 1/2 Study of Lumasiran for Treatment of Primary Hyperoxaluria Type 1: A Placebo-Controlled Randomized Clinical Trial.
1/2021	Natural History of Clinical, Laboratory, and Echocardiographic Parameters of a Primary Hyperoxaluria Cohort on Long Term Hemodialysis.
1/2021	Excretion of urine extracellular vesicles bearing markers of activated immune cells and calcium/phosphorus physiology differ between calcium kidney stone formers and non-stone formers.

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John C Lieske Research Topics

Disease

40	Kidney Calculi (Kidney Stone) 09/2022 - 09/2004
28	Hyperoxaluria (Oxaluria) 07/2022 - 09/2005
22	Primary Hyperoxaluria (Oxaluria, Primary) 01/2022 - 05/2005
20	Chronic Renal Insufficiency 01/2022 - 05/2009
18	Nephrolithiasis 01/2022 - 07/2003
15	Nephrocalcinosis 09/2022 - 07/2004
15	Hypertension (High Blood Pressure) 10/2020 - 12/2006
14	Primary hyperoxaluria type 1 09/2022 - 01/2020
14	Renal Insufficiency (Renal Failure) 09/2022 - 05/2005
12	Obesity 01/2021 - 09/2005
12	Proteinuria 12/2020 - 10/2013
11	Chronic Kidney Failure (Chronic Renal Failure) 05/2020 - 05/2005
9	Inborn Genetic Diseases (Disease, Hereditary) 07/2022 - 08/2011
9	Urinary Calculi (Urinary Calculus) 03/2022 - 01/2010
8	Hypercalciuria 03/2022 - 05/2004
7	Kidney Diseases (Kidney Disease) 07/2022 - 01/2009
7	Acute Kidney Injury (Acute Renal Failure) 01/2020 - 05/2013
6	Urolithiasis 01/2021 - 05/2005
5	Membranous Glomerulonephritis (Membranous Nephropathy) 01/2021 - 01/2015
5	Cardiovascular Diseases (Cardiovascular Disease) 03/2014 - 09/2008
4	Focal Segmental Glomerulosclerosis (Glomerulosclerosis, Focal) 01/2021 - 08/2013
4	Cystinuria 11/2020 - 08/2011
4	Neoplasms (Cancer) 11/2020 - 01/2018
4	Dent Disease 01/2020 - 08/2011
4	Urinary Tract Infections (Urinary Tract Infection) 04/2016 - 01/2010
3	Injection Site Reaction 07/2022 - 01/2021
3	Cysts 03/2022 - 05/2012
3	Calculi (Calculus) 01/2022 - 12/2004
3	Body Weight (Weight, Body) 01/2021 - 01/2016
3	Albuminuria 12/2020 - 06/2013
3	Fibrosis (Cirrhosis) 11/2020 - 01/2016
3	Diabetes Mellitus 01/2020 - 02/2012
3	Gout 03/2017 - 04/2009
3	Hypertrophy 07/2016 - 11/2014
3	Shock 01/2013 - 01/2011
2	Water Intoxication 05/2022 - 01/2022
2	Rare Diseases (Rare Disease) 01/2022 - 01/2021
2	Hypercalcemia (Milk Alkali Syndrome) 07/2021 - 01/2015
2	Gastrointestinal Diseases (Functional Gastrointestinal Disorders) 01/2021 - 07/2013
2	Inflammation (Inflammations) 01/2021 - 04/2016
2	Atrophy 11/2020 - 01/2016
2	Nephrosclerosis 11/2020 - 01/2016
2	Infections 10/2018 - 01/2010
2	Hyperuricemia 01/2018 - 01/2017
2	Lipoid Nephrosis (Glomerulonephritis, Minimal Change) 10/2017 - 11/2015
2	Dyslipidemias (Dyslipidemia) 03/2017 - 04/2009
2	Alcoholism (Alcohol Abuse) 03/2017 - 04/2009
2	Coronary Artery Disease (Coronary Atherosclerosis) 03/2017 - 04/2009
2	Nephrotic Syndrome (Syndrome, Nephrotic) 11/2016 - 11/2015
2	Neurogenic Urinary Bladder (Bladder, Neurogenic) 12/2014 - 09/2012

Drug/Important Bio-Agent (IBA)

35	OxalatesIBA 07/2022 - 11/2004
27	CreatinineIBA 07/2022 - 04/2009
22	Calcium OxalateIBA 01/2022 - 05/2004
14	CalciumIBA 01/2022 - 05/2005
13	AlbuminsIBA 12/2020 - 09/2008
12	Proteins (Proteins, Gene)FDA Link 02/2021 - 07/2003
11	Cystatin CIBA 12/2021 - 03/2012
11	Uric Acid (Urate)IBA 01/2019 - 12/2006
9	Biomarkers (Surrogate Marker)IBA 07/2022 - 05/2013
6	lumasiranIBA 07/2022 - 01/2020
6	Citric Acid (Citrate)FDA LinkGeneric 05/2022 - 03/2008
6	StruviteIBA 01/2021 - 01/2010
4	UromodulinIBA 01/2018 - 07/2003
4	calcium phosphateIBA 11/2017 - 12/2007
4	Biological ProductsIBA 01/2011 - 06/2008
3	EnzymesIBA 05/2022 - 05/2013
3	Pyridoxine (Pyridoxin)FDA LinkGeneric 05/2022 - 06/2020
3	Phosphorus (Red Phosphorus)IBA 05/2022 - 12/2007
3	Vitamin D3 24-HydroxylaseIBA 03/2022 - 01/2021
3	Vitamin D FDA LinkGeneric 03/2022 - 01/2015
3	Pharmaceutical PreparationsIBA 01/2022 - 10/2004
3	dihydrate dibasic calcium phosphate (brushite)IBA 01/2021 - 12/2007
3	Cystine (L-Cystine)IBA 11/2020 - 06/2011
3	Chemokine CCL2 (Monocyte Chemoattractant Protein 1)IBA 01/2020 - 01/2016
3	Iothalamic Acid (Iotalamic Acid)FDA Link 01/2020 - 03/2012
3	Calcifying NanoparticlesIBA 01/2014 - 09/2004
2	Phosphates (Orthophosphate)IBA 03/2022 - 04/2008
2	1,25-dihydroxyvitamin DIBA 03/2022 - 01/2015
2	Vancomycin FDA LinkGeneric 12/2020 - 05/2017
2	Ascorbic Acid (Vitamin C)FDA LinkGeneric 01/2019 - 11/2004
2	Rituximab (Mabthera)FDA Link 01/2019 - 01/2015
2	AngiotensinsIBA 01/2019 - 01/2018
2	Cyclosporine (Ciclosporin)FDA LinkGeneric 01/2019 - 01/2015
2	SteroidsIBA 10/2017 - 12/2016
2	Triglycerides (Triacylglycerol)IBA 01/2016 - 06/2013
2	ElectrolytesIBA 11/2015 - 01/2015
2	Durapatite (Hydroxylapatite)IBA 12/2013 - 05/2009

Therapy/Procedure

13	Therapeutics 05/2022 - 01/2010
7	Gastric Bypass (Roux-en-Y Gastric Bypass) 01/2021 - 09/2005
5	Lithotripsy (Extracorporeal Shockwave Lithotripsy) 01/2013 - 09/2005
4	Renal Dialysis (Hemodialysis) 07/2022 - 09/2005
4	Nephrectomy 01/2022 - 01/2018
4	Bariatric Surgery 01/2021 - 03/2008
3	Transplantation 12/2020 - 01/2016
3	Kidney Transplantation 01/2019 - 05/2005
3	Urinary Diversion (Ileal Conduit) 09/2012 - 01/2010
2	Liver Transplantation 05/2022 - 01/2020
2	RNAi Therapeutics 11/2021 - 01/2021
2	Traditional Medicine (Folk Remedies) 04/2015 - 10/2004
2	Percutaneous Nephrolithotomy 10/2013 - 01/2013